Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency
View/ Open
Descargar
(application/pdf: 1.950Mb)
(application/pdf: 1.950Mb)
Date
2023-03-07Author(s)
Al Ouqaili, Mushtak T. S.
Saleh, Raed Obaid
Amin, Hawraz Ibrahim M.
Jawhar, Zanko Hassan
Akbarizadeh, Majid Reza
Naderifar, Mahin
Issa, Kovan Dilawer
Gavilán, Juan Carlos Orosco
Nobre, Marcos Augusto Lima
Jalil, Abduladheem Turki
Akhavan Sigari, Reza
Metadata
Show full item recordAbstract
One of the current concerns to human health is antibiotic resistance, which promotes the use of antibiotics that are more harmful, expensive, and ineffective. In this condition, researchers are turning to innovative options to combat this alarming situation. Combining herbal medicine with nanotechnology has created a new strategy to increase the effectiveness of phytochemical compounds in overcoming antimicrobial resistance. Pistacia atlantica is one of the promising herbs with medicinal benefits, but its poor solubility in biological fluids is challenging. In this regard, we seek to evaluate the antibacterial efficacy of Pistacia atlantica extract-loaded nanovesicle. Cholesterol, Span 40, and Pluronic F127 modified nanoformulation was developed using an environmentally friendly improved heating technique, and it was evaluated for size distribution, zeta potential, morphology, entrapment efficiency (EE%), release behavior, stability, and antimicrobial performance. By using DLS, spherical nanovesicles were identified with a size distribution of 50–150 nm and a zeta potential of −43 mV. The extract's encapsulation efficiency was 72.03%. The developed loaded nanovesicles demonstrated controlled extract release in the tested 96 h and storage stability of at least 12 months at 25 °C. Also, Comparing the two samples, the encapsulated extract had greater antibacterial activity against Candida albicans, Staphylococcus aureus, and Pseudomonas plecoglossicida with MIC of 1320, 570, and 1100 µg/mL, respectively. Besides reducing the misuse of antibiotics by allowing for the controlled release of drugs made from natural sources, we expect the findings described here to help provide alternative plant-based formulations with greater stability and antibacterial activity.
Mostrar más
Bibliographic citation
Al, M. T., Saleh, R. O., Amin, H. I., Jawhar, Z. H., Akbarizadeh, M. R., Naderifar, M., Issa, K. D., Gavilán, J. C., Nobre, M. A., Jalil, A. T., & Akhavan, R. (2023). Synthesize of pluronic-based nanovesicular formulation loaded with Pistacia atlantica extract for improved antimicrobial efficiency. Arabian Journal of Chemistry, 16(6), 104704. https://doi.org/10.1016/j.arabjc.2023.104704
Collections
The following license files are associated with this item:
Related items
Showing items related by title, author, creator and subject.
-
Influencia del tamaño de partícula de mineral oxidado y concentración del lixiviante en extracción de oro mediante lixiviación en columna, Sayapullo - La Libertad
Alaya Misahuamán, Jeanpierre Jhanmarco (Universidad Privada del Norte, 2017-09-19)Acceso cerradoRESUMEN La presente investigación tiene como objetivo mejorar la extracción de oro en un proceso de lixiviación por percolación, en este caso en columnas, utilizando la técnica de investigación experimental trifactorial, ... -
Implementación de un sistema de extracción de monóxido, para minimizar el costo energético en el estacionamiento de naranjal de una empresa rubro automotor, año 2016
Estrada Lopez, Miguel Angel (Universidad Privada del Norte, 2017-05-30)Acceso cerradoRESUMEN La presente tesis se desarrolló para la implementación de un sistema de extracción de monóxido, para minimizar el costo energético en un estacionamiento subterráneo. Es muy importante que los estacionamientos ... -
Mixing Design for Optimizing Ultrasound-Assisted Extraction of Phenolic Components and Anthocyanins from Blue Berries and Grape Marc
Zevallos, Lady; Caldas, César; Flores, Alberto; Obregón, Jesús; Miano, Alberto Claudio; Barraza-Jáuregui, Gabriela (Taylor & Francis, 2020-07-07)Acceso abiertoABSTRACT Waste from fruit processing can be used for obtaining additives as colorants and antioxidant compounds by extraction processes. Despite there are many works optimizing parameters as temperature and solvent ...